New analysis concludes apixaban best option for atrial fibrillation
نویسندگان
چکیده
منابع مشابه
Apixaban in patients with atrial fibrillation.
BACKGROUND Vitamin K antagonists have been shown to prevent stroke in patients with atrial fibrillation. However, many patients are not suitable candidates for or are unwilling to receive vitamin K antagonist therapy, and these patients have a high risk of stroke. Apixaban, a novel factor Xa inhibitor, may be an alternative treatment for such patients. METHODS In a double-blind study, we rand...
متن کاملApixaban (eliquis) for stroke prevention in atrial fibrillation.
Apixaban has a lower risk of bleeding than warfarin, but a slightly higher risk of minor bleeding compared with aspirin. One additional major bleeding episode (defined as clinically overt bleeding accompanied by a hemoglobin decrease of 2 g per dL [20 g per L] and occurring at a critical site or resulting in death) will be prevented for every 66 patients treated with apixaban instead of warfari...
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Atrial fibrillation (AF) is the most common cardiac arrhythmia which increases the risk of stroke and systemic embolism by 5- fold, it is a major global public health problem. Stroke is associated with greatest mortality and morbidity in patients with AF. Strokes associated with AF are especially large and disabling, and consequently primary prevention is paramount. Antithrombotic therapy is th...
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Almost 800,000 new or recurrent strokes occur every year. Atrial fibrillation, the most common cardiac arrhythmia, is a major risk factor for stroke, accounting for 15-20% of ischemic strokes. Apixaban is a direct inhibitor of Factor Xa that was approved in December 2012 by the US Food and Drug Administration (FDA) for the prevention of stroke in patients with non-valvular atrial fibrillation. ...
متن کاملCritique of apixaban versus warfarin in patients with atrial fibrillation.
For stroke prevention in atrial fibrillation (AF), warfarin has been the king of the castle for more than half a century. Recently, some serious contenders have threatened its dominance by claiming therapeutic equivalence and a better benefit–risk profile. These novel agents, oral direct thrombin or factor Xa inhibitors, have kindled anticipation of “a new era for anticoagulation in AF.”1 On Au...
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ژورنال
عنوان ژورنال: Pharmacy Today
سال: 2018
ISSN: 1042-0991
DOI: 10.1016/j.ptdy.2018.01.003